The human fovea is known for its distinctive pit‐like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces (...) acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta‐analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development. (shrink)

ImportancePrevious studies of post-acute COVID-19 syndrome have focused on critical cases with severe disease. However, most cases are mild to moderate in disease severity.ObjectiveWe aimed to examine cognitive outcomes in cases of non-critical, mild-to-moderate COVID-19. Design, Setting, and Participants: In this cross-sectional study, we enrolled 72 adults aged 22 to 65 years in Central Texas who had non-critical, mild-to-moderate COVID-19 infection between 13 January 2021 and 20 April 2021.Main Outcomes and MeasuresWe remotely administered cognitive-behavioral testing to determine the frequency of (...) cognitive impairment and examine demographic, clinical, and psychosocial contributors to impairment.ResultsThe frequency of objective cognitive impairment was 40%. The largest number of participants showed impairment on a measure of executive functioning. Attention and processing speed was more impaired in males. Males endorsed lower adherence to social distancing guidelines, which was in turn associated with cognitive impairment across participants. Younger age was correlated with impairment but was also associated with racial/ethnic minority status and increased psychological symptoms. Moderate COVID-19 severity was associated with attention/processing speed impairment, increased pain, and higher number of COVID-19 symptoms.Conclusion and RelevanceMild or moderate COVID-19 infection may be associated with cognitive impairments, especially in the domain of executive functioning. A subgroup of younger individuals may be more vulnerable to cognitive and psychosocial effects of COVID-19.HighlightsQuestion: How frequent is cognitive impairment among non-critical, mild-to-moderate COVID-19 survivors?FindingsIn this cross-sectional study of 72 adults, 40% demonstrated cognitive impairment, particularly in executive function.MeaningNeurologic sequelae, such as cognitive impairment, may be common following COVID-19 infection. (shrink)

How the rational imagination develops remains an open question. The ability to imagine emerges early in childhood, well before the ability to reason counterfactually, and this suggests that imaginative thought may facilitate later counterfactual ability. In addition, developmental data indicate that inhibitory control may also play a role in the ability to reason counterfactually.

An ongoing debate in affective science concerns whether certain discrete, “basic” emotions have evolutionarily based signals that are easily, universally, and innatel...

La respuesta a la pregunta del título se ofrece en tres niveles. A veces las diferencias se deben a las limitaciones del equipo empleado, deficiencias en el muestreo o preferencias en la interpretación de los datos. Otras veces se deben a que los investigadores operan en base a paradigmas diferentes..

The process by which emotion concepts are learned is largely unexplored. Hoemann, Devlin, and Barrett and Shablack, Stein, and Lindquist argue that emotion concepts are learned throug...

"Characterized by breadth of coverage, a refreshingly balanced approach to controversial issues, & a highly readable style."-Theological Studies.

Contending that concern over the ethical dimensions of these and other like issues are no longer just in the domain of those involved in medical practice, the ...

Working from a realist Thomistic epistemology, Ashley asserts that we must begin our search for wisdom in the natural sciences; only then, he believes, can we ensure that our claims about immaterial and invisible things are rooted in reliable experience of the material. Any attempt to share wisdom, he insists, must derive from a context that is both interdisciplinary and intercultural. Ashley offers an ambitious analysis and synthesis of major historical contributions to the unification of knowledge, including non-Western (...) traditions. Beginning with the question "Metaphysics: Nonsense or Wisdom?" Ashley moves from a critical examination of the foundations of modern science to quantum physics and the Big Bang; from Aristotle's theory of being and change, through Aquinas's five ways, to a critical analysis of modern and postmodern thought. Ashley is able to interweave the approaches of the great philosophers by demonstrating their contributions to philosophical thought in a concrete, specific manner. In the process, he accounts for a contemporary culture overwhelmed by the fragmentation of data and thirsting for an utterly transcendent yet personal God. "This is an impressive, well-researched book, of great value. It offers the wider philosophical community a point of entrance, by a proponent of a certain type of Thomism, into a domain that all philosophers think they already understand. The result is the creation of a 'big picture' of human knowledge." -- _Mark Johnson, Marquette University_. (shrink)